One of my close friends Deepak Singh who is also my colleague at work is suffering from Blood Cancer. He has used up all his savings in the current treatment and is advised to do bone marrow transplant in April. I need help from everyone of you who is reading this to gather funds of Rs.20,00,000 which would help him undergo the advised treatment. Alone it would be a huge burden for him but if we all stand by him he would be able to fight the cancer and the condition that he is facing, request all to be generous and help out!!
Details of his type of cancer and treatment advised are mentioned below for your reference,
FLT3/NPM1/CEBPA: Not Detected
He is a 29yrs old patient, non-diabetic male presented on 26/11/16 with c/o weakness, dizziness, fatigue and breathlessness on exertion since 5 months. Patient evaluated for the same and found to have low HB for which he received 4 units of packed cells. Last blood transfusion was given on 20.11.16.
Father & Mother alive and healthy. 3 sisters. Married and 1 male child.
On Examination :
PS2, pallor+, fully oriented, afebrile, vitals: stable, no lymphadenopathy, no gum hypertrophy.
CNS: Conscious, Oriented.
Chest : Clear
P/A: soft, no organomegaly.
Co- Morbidity : HT : No, DM: No, Others: No
He was evaluted with HB: 5, plt : 23000 with progressive fall.
Peripheral Smear : Leucoerythroblastic picture with 5% blast.
Bone Marrow aspiration (28/11/16) : MDS-RAEB2 (14% Blast)
Bone Marrow Biopsy (28/11/16) : Showing ~95% marrow cellularity. There is marked myeloid prominence. Megakaryocytes are showing displastic changes. Interstially scattered immature cells are seen. No large sheet or cluster of blast seen.
Cytogenetics : 46 X,Y
Flow Cytometry Report : Samplee show 10% abnormal events which are positive for myeloid markers along with aberrant cd19 & cd7. Positive for CD34, HLA-DR, Myeloperoxidase, CD117, CD13, CD11c, CD19, CD38 and Negative for CD64, CD10, CD79A, CD22, CD20, CD3, CD5, CD7.
FLT3 Mutations Assay : NOT DETECTED.
NPM1/CEBPA Mutations : No Mutations were detected.
C.Difficle Toxin a&'b' symptoms : Negative
Vitamin D : 21.8
Bone Marrow aspiration (17/12/16) : Marked diluted aspirate smear showing predominantly mature lymphocytes and 6% blasts. Peripheral smear shows pancytopenia.
Bone Marrow Biopsy (17/12/16) : Hypocellular marrow (Post chemotherapy) with persistent disease. Addendum report on 24/12/16 IHC for CD34 is Negative.
IHC for CD117 shows increased immature cells and is positive in ~20~25% of all hemooietic cells.
Bone Marrow aspiration (03/01/17) : Blast Constitute 6% (29/500) of all nucleated cells . Occasional Blasts show auer rods. Bone marrow is not in morphological remission.
Patient was admitted on 03/12/2016 for induction chemotherapy(3+7) with Inj Daunorubicin and Inj Cytarabine from 04.12.2016 to 10.12.2016
Patient has no matched sibling so he was plan for MUD allogenic stem cell transplant till he get match donor, he was plan to give Decitabine based chemotherapy.
Action Plan : Stem Cell Transplant scheduled in April 2017 from First Cousin with 8/10 match.